Diabetologia. 2025 Dec 8. doi: 10.1007/s00125-025-06613-1. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: The aetiology of type 1 diabetes remains elusive. Family history of type 1 diabetes increases the disease risk but the role of other autoimmune diseases or type 2 diabetes in the family are unclear. Here, we aimed to…
Author: Henok Karvonen
Association of behaviour-related health risk factors with working life expectancy in adults aged ≥ 50 years: findings from the English Longitudinal Study of Ageing and the Finnish Public Sector Study
Eur J Ageing. 2025 Nov 29. doi: 10.1007/s10433-025-00896-4. Online ahead of print. ABSTRACT BACKGROUND: Behaviour-related health risk factors are associated with an increased risk of early exit from the working life, but their contribution to working life expectancy (WLE) remains unclear. We investigated the associations of obesity, alcohol intake, smoking…
Differential effects of adolescent health behaviours on adult cardiometabolic health by parental and neighbourhood socioeconomic background
Eur J Public Health. 2025 Nov 22:ckaf212. doi: 10.1093/eurpub/ckaf212. Online ahead of print. ABSTRACT Adolescent healthy behaviours may improve cardiometabolic health in adulthood differently across socioeconomic groups. We aimed to quantify the effects of adolescent healthy behaviours on multiple biomarkers of adult cardiometabolic health by socioeconomic backgrounds. We used a…
Dynamics of gut metabolome and microbiota maturation during early life
iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21. ABSTRACT Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This study investigates the gut metabolites, including short-chain fatty acids (SCFAs), bile acids (BAs), and…
Associations of long-term cumulative C-reactive protein and glycoprotein acetyls concentrations in childhood, adolescence and adulthood with adulthood retinal microvascular structure
Atherosclerosis. 2025 Nov 20;412:120595. doi: 10.1016/j.atherosclerosis.2025.120595. Online ahead of print. ABSTRACT BACKGROUNG AND AIMS: Inflammation is associated with cardiovascular disease development and microvascular dysfunction. The aim of the present study is to test the hypothesis that long-term exposure to chronic inflammation in childhood and adulthood is associated with adverse retinal…
Associations between cumulative family environmental stress exposures and hair cortisol concentrations among 2.5- and 5-year-olds with different social competences
Horm Behav. 2025 Nov 22;177:105862. doi: 10.1016/j.yhbeh.2025.105862. Online ahead of print. ABSTRACT There is a vast amount of research indicating the associations between prenatal and postnatal environmental stress exposures and the human hypothalamic-pituitary-adrenal (HPA) axis functioning in early childhood. However, less is known about the protective factors among these associations.
Duration and mode of delivery: Does maternal sleep matter?
Int J Gynaecol Obstet. 2025 Nov 20. doi: 10.1002/ijgo.70673. Online ahead of print. ABSTRACT OBJECTIVE: Poor sleep quality in late pregnancy has been identified as a risk factor for operative deliveries. In this study, we investigated the associations between maternal sleep throughout pregnancy and its impact on both the duration…
Very-Early Onset Autoimmune Hypothyroidism: A Report of Two Cases with STAT3 Gain-Of-Function Variant
Eur Thyroid J. 2025 Nov 20:ETJ-25-0260. doi: 10.1530/ETJ-25-0260. Online ahead of print. ABSTRACT Autoimmune hypothyroidism occurs rarely before three years of age. Two siblings were diagnosed with autoimmune hypothyroidism at age five and 16 months, presenting with classic symptoms of hypothyroidism, abnormal thyroid function tests (TSH 200 and 660 mU/L;…
Islet autoimmunity and progression to type 1 diabetes in the Finnish DIPP study: comparison between genetically susceptible children with and without an affected first-degree relative
Diabetologia. 2025 Nov 8. doi: 10.1007/s00125-025-06573-6. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: Islet autoimmunity during presymptomatic type 1 diabetes is heterogeneous. We hypothesised that a positive family history of type 1 diabetes is associated with specific characteristics of the autoimmune process resulting in clinical diabetes. In a prospective birth cohort…
Osteosarcopenia as a risk factor for fractures and mortality – 19-year follow-up of a population-based sample
Aging Clin Exp Res. 2025 Nov 6;37(1):319. doi: 10.1007/s40520-025-03229-8. ABSTRACT PURPOSE: This study assessed osteoporosis, sarcopenia and osteosarcopenia as risk factors for fractures and mortality during 19-year follow-up. METHODS: We analyzed 2506 individuals aged ≥ 55 from the Finnish Health 2000 Survey. Probable sarcopenia was defined as grip strength <…
