Int J Mol Sci. 2022 Dec 11;23(24):15726. doi: 10.3390/ijms232415726. ABSTRACT Only 3-5% of heavy alcohol users develop acute alcohol pancreatitis (AAP). This suggests that additional triggers are required to initiate the inflammatory process. Genetic susceptibility contributes to the development of AAP, and SPINK1 mutation is a documented risk factor. We…
Author: Henok Karvonen
Effect of menopause and age on vascular impairment
Maturitas. 2023 Mar;169:46-52. doi: 10.1016/j.maturitas.2023.01.006. Epub 2023 Jan 18. ABSTRACT AIMS: The prevalence of cardiovascular diseases increases in women after menopause. The aim of the study was to determine the impact of conventional cardiovascular risk factors such as age, blood pressure, smoking, cholesterol, obesity, and glucose balance, but also menopausal…
Changes in life satisfaction during the transition to retirement: findings from the FIREA cohort study
Eur J Ageing. 2022 Dec;19(4):1587-1599. doi: 10.1007/s10433-022-00745-8. Epub 2022 Nov 23. ABSTRACT Life satisfaction is an essential construct of well-being that is tied to behavioral, emotional, social and psychological outcomes. This study aimed to examine changes in total and domain-specific life satisfaction during the retirement transition and additionally examine whether…
Work ability and physical fitness among aging workers: the Finnish Retirement and Aging Study
Eur J Ageing. 2022 Dec;19(4):1301-1310. doi: 10.1007/s10433-022-00714-1. Epub 2022 Jun 22. ABSTRACT BACKGROUND: With advancing age, physical capacity gradually decreases which may lead to decreased work ability, if the physical work requirements remain the same. Examination of the importance of physical fitness for work ability among aging workers will help…
Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study
Lancet Child Adolesc Health. 2023 Apr;7(4):261-268. doi: 10.1016/S2352-4642(22)00350-9. Epub 2023 Jan 18. ABSTRACT BACKGROUND: Screening for islet autoantibodies in children and adolescents identifies individuals who will later develop type 1 diabetes, allowing patient and family education to prevent diabetic ketoacidosis at onset and to enable consideration of preventive therapies. We…
Cross-sectionally calculated metabolic ageing does not relate to longitudinal metabolic changes – support for stratified ageing models
J Clin Endocrinol Metab. 2023 Jan 20:dgad032. doi: 10.1210/clinem/dgad032. Online ahead of print. ABSTRACT CONTEXT: Ageing varies between individuals with profound consequences for chronic diseases and longevity. One hypothesis to explain the diversity is a genetically regulated molecular clock that runs differently between individuals. Large and long enough human studies…
Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study
BMC Med. 2023 Jan 18;21(1):23. doi: 10.1186/s12916-022-02711-8. ABSTRACT BACKGROUND: Common pregnancy and perinatal complications are associated with offspring cardiometabolic risk factors. These complications may influence multiple metabolic traits in the offspring and these associations might differ with offspring age. METHODS: We used data from eight population-based cohort studies to examine…
Course of child social-emotional and sleep symptoms, parental distress and pandemic-related stressors during COVID-19
Dev Psychopathol. 2023 Feb 16:1-15. doi: 10.1017/S0954579422001377. Online ahead of print. ABSTRACT Research on the longitudinal courses of child social-emotional symptoms and sleep during the COVID-19 pandemic within societies would be of key value for promoting child well-being in global crises. We characterized the course of children’s social-emotional and sleep…
Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study
BMC Med. 2023 Feb 14;21(1):57. doi: 10.1186/s12916-023-02743-8. ABSTRACT BACKGROUND: An extensive body of animal literature supports the premise that maternal obesity during pregnancy can alter the development of the fetal hypothalamus (HTH, a critical regulator of energy balance) with implications for offspring obesity risk (i.e., long-term energy imbalance). Yet, the…
A new blood based epigenetic age predictor for adolescents and young adults
Sci Rep. 2023 Feb 9;13(1):2303. doi: 10.1038/s41598-023-29381-7. ABSTRACT Children have special rights for protection compared to adults in our society. However, more than 1/4 of children globally have no documentation of their date of birth. Hence, there is a pressing need to develop biological methods for chronological age prediction, robust…
