OMICS. 2023 May;27(5):193-204. doi: 10.1089/omi.2023.0028. Epub 2023 May 5. ABSTRACT Advanced integrative analysis of DNA methylation and transcriptomics data may provide deeper insights into smoke-induced epigenetic alterations, their effects on gene expression and related biological processes, linking cigarette smoking and related diseases. We hypothesize that accumulation of DNA methylation changes…
Author: Henok Karvonen
The relationship of trait-like compassion with epigenetic aging: The population-based prospective Young Finns Study
Front Psychiatry. 2023 Apr 18;14:1018797. doi: 10.3389/fpsyt.2023.1018797. eCollection 2023. ABSTRACT INTRODUCTION: Helping others within and beyond the family has been related to living a healthy and long life. Compassion is a prosocial personality trait characterized by concern for another person who is suffering and the motivation to help. The current…
Possible heterogeneity of initial pancreatic islet beta-cell autoimmunity heralding type 1 diabetes
J Intern Med. 2023 May 4. doi: 10.1111/joim.13648. Online ahead of print. ABSTRACT The etiology of type 1 diabetes (T1D) foreshadows the pancreatic islet beta-cell autoimmune pathogenesis that heralds the clinical onset of T1D. Standardized and harmonized tests of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A),…
Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15-Year-Old Children Followed in the TEDDY Study
Diabetes Care. 2023 May 4:dc230036. doi: 10.2337/dc23-0036. Online ahead of print. ABSTRACT OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years. RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of…
Gut microbiota composition and function in pregnancy as determinants of prediabetes at two-year postpartum
Acta Diabetol. 2023 Apr 28. doi: 10.1007/s00592-023-02064-5. Online ahead of print. ABSTRACT AIMS: Deep metagenomics offers an advanced tool for examining the relationship between gut microbiota composition and function and the onset of disease; in this case, does the composition and function of gut microbiota during pregnancy differ in women…
Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts
Pediatr Allergy Immunol. 2023 Apr;34(4):e13945. doi: 10.1111/pai.13945. ABSTRACT BACKGROUND: Urban-related nature exposures are suggested to contribute to the rising prevalence of allergic diseases despite little supporting evidence. Our aim was to evaluate the impact of 12 land cover classes and two greenness indices around homes at birth on the development…
Spillover effects of the COVID-19 pandemic on attitudes to influenza and childhood vaccines
BMC Public Health. 2023 Apr 25;23(1):764. doi: 10.1186/s12889-023-15653-4. ABSTRACT The current study sought to determine whether public perceptions of other vaccines and diseases than COVID-19 have been impacted by the COVID-19 pandemic. We longitudinally examined whether there had been a change from before the COVID-19 pandemic to during the pandemic…
What is the role of puberty in the development of islet autoimmunity and progression to type 1 diabetes?
Eur J Epidemiol. 2023 Jun;38(6):689-697. doi: 10.1007/s10654-023-01002-7. Epub 2023 Apr 20. ABSTRACT In many populations, the peak period of incidence of type 1 diabetes (T1D) has been observed to be around 10-14 years of age, coinciding with puberty, but direct evidence of the role of puberty in the development of…
Prenatal maternal depressive symptoms are associated with neonatal left amygdala microstructure in a sex-dependent way
Eur J Neurosci. 2023 May;57(10):1671-1688. doi: 10.1111/ejn.15989. Epub 2023 May 2. ABSTRACT Exposures to prenatal maternal depressive symptoms (PMDS) may lead to neurodevelopmental changes in the offspring in a sex-dependent way. Although a connection between PMDS and infant brain development has been established by earlier studies, the relationship between PMDS…
Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system
Dev Psychopathol. 2023 Apr 3:1-16. doi: 10.1017/S0954579423000275. Online ahead of print. ABSTRACT Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap.
