Nat Commun. 2023 Mar 7;14(1):1271. doi: 10.1038/s41467-023-36862-w. ABSTRACT Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due…
Author: Henok Karvonen
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
Diabetes Care. 2023 May 1;46(5):1014-1018. doi: 10.2337/dc22-1359. ABSTRACT OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study,…
Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system
Dev Psychopathol. 2023 Apr 3:1-16. doi: 10.1017/S0954579423000275. Online ahead of print. ABSTRACT Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap.
Association of Sit-to-Stand Capacity and Free-Living Performance Using Thigh-Worn Accelerometers among 60-90-Year-Old Adults
Med Sci Sports Exerc. 2023 Apr 3. doi: 10.1249/MSS.0000000000003178. Online ahead of print. ABSTRACT PURPOSE: Five times sit-to-stand (STS) test is commonly used as a clinical assessment of lower-extremity functional ability, but its association with free-living performance has not been studied. Therefore, we investigated the association between laboratory-based STS capacity…
Higher attention bias for fear at 8 months of age is associated with better socioemotional competencies during toddlerhood
Infant Behav Dev. 2023 May;71:101838. doi: 10.1016/j.infbeh.2023.101838. Epub 2023 Mar 28. ABSTRACT BACKGROUND: In previous studies, an attention bias for signals of fear and threat has been related to socioemotional problems, such as anxiety symptoms, and socioemotional competencies, such as altruistic behaviors in children, adolescents and adults. However, previous studies…
Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative
Toxics. 2023 Mar 4;11(3):241. doi: 10.3390/toxics11030241. ABSTRACT Phthalates are mainly used as plasticizers and are associated inter alia with adverse effects on reproductive functions. While more and more national programs in Europe have started monitoring internal exposure to phthalates and its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from…
Pre- and postnatal maternal depressive symptoms associate with white matter integrity in 5-year-olds in sex-specific manner
Biol Psychiatry. 2023 May 21:S0006-3223(23)01301-X. doi: 10.1016/j.biopsych.2023.05.014. Online ahead of print. ABSTRACT BACKGROUND: Pre- and postnatal maternal psychological distress predicts various detrimental consequences on social, behavioural, and cognitive development of the offspring and especially in girls. Maturation of white matter (WM) continues from prenatal development into adulthood and is thus…
Longitudinal consumption of fruits and vegetables and risk of asthma by 5 years of age
Pediatr Allergy Immunol. 2023 Mar;34(3):e13932. doi: 10.1111/pai.13932. ABSTRACT BACKGROUND: Fruit and vegetable consumption has been linked to a decreased risk of asthma, but prospective evidence on longitudinal consumption in childhood is scarce. We aimed to investigate the association between fruit and vegetable consumption in childhood and the risk of asthma…
Associations of active commuting to school in childhood and physical activity in adulthood
Sci Rep. 2023 May 11;13(1):7642. doi: 10.1038/s41598-023-33518-z. ABSTRACT This study examined whether active commuting to school in childhood and adolescence predicted active commuting to work and overall physical activity (PA) in adulthood. Participants from the Young Finns Study (N = 2436) were aged 9-18 years in 1980 and followed up…
Workplace Psychosocial Resources and Risk of Sleep Disturbances Among Employees
JAMA Netw Open. 2023 May 1;6(5):e2312514. doi: 10.1001/jamanetworkopen.2023.12514. ABSTRACT IMPORTANCE: Workplace psychosocial resources naturally tend to cluster in some work teams. To inform work-related sleep health promotion interventions, it is important to determine the associations between clustering of workplace resources and sleep disturbances when some resources are high while others…
