Anal Chem. 2024 Dec 16. doi: 10.1021/acs.analchem.4c03229. Online ahead of print. ABSTRACT Applications of advanced omics methodologies are increasingly popular in biomedicine. However, large-scale studies aiming at clinical translation are typically siloed to single technologies. Here, we present the first comprehensive large-scale population data combining 209 lipoprotein measures from a…
Publications
Publications
Understanding lipidomics associations and the lipoprotein-related caveats in population epidemiology
Am J Epidemiol. 2024 Nov 28:kwae445. doi: 10.1093/aje/kwae445. Online ahead of print. ABSTRACT Mass spectrometry lipidomics is becoming customary to analyse serum/plasma samples in epidemiology. The measurables are molecular constituents of lipoprotein particles, but very little is known on the consequences of adjusting lipidomics data with lipoprotein measures. We studied…
Association between job strain and working life expectancy: a longitudinal study of older people in Sweden
Eur J Public Health. 2024 Dec 12:ckae186. doi: 10.1093/eurpub/ckae186. Online ahead of print. ABSTRACT Many European countries have increased retirement ages to address the challenge of population ageing. However, job strain which is the combination of high job demands and low job control may be an obstacle to extending the…
Associations of Cumulative Adulthood, Childhood and Life-long Insulin with Adulthood Retinal Microvasculature
J Clin Endocrinol Metab. 2024 Dec 11:dgae865. doi: 10.1210/clinem/dgae865. Online ahead of print. ABSTRACT CONTEXT: Exogenous insulin is reported to have both vasodilatory and vasoconstrictive effects on the microvasculature. Little is known about the associations of long-term endogenous insulin exposure with microvasculature. OBJECTIVE: To test the hypothesis that long-term exposure…
Understanding Resilience in Parents: Longitudinal Examination of Trait Resilience, Stressful Life Events, and Psychological Distress Symptoms-Insights From the FinnBrain Study
Stress Health. 2024 Dec 2:e3516. doi: 10.1002/smi.3516. Online ahead of print. ABSTRACT The study aimed to investigate the persistence or changes in trait resilience of parents over a 6-year period and its association with stressful life events (SLEs). Furthermore, we explored the potential protective effect of trait resilience against exposure…
Efficient Search Algorithms for Identifying Synergistic Associations in High-Dimensional Datasets
Entropy (Basel). 2024 Nov 11;26(11):968. doi: 10.3390/e26110968. ABSTRACT In recent years, there has been a notably increased interest in the study of multivariate interactions and emergent higher-order dependencies. This is particularly evident in the context of identifying synergistic sets, which are defined as combinations of elements whose joint interactions result…
Low-Density Lipoprotein Cholesterol Level Distributions Across Different Ages: Implications for Screening Children for Severe and Familial Hypercholesterolemia
Circulation. 2024 Nov 19;150(21):1741-1744. doi: 10.1161/CIRCULATIONAHA.124.069792. Epub 2024 Nov 18. NO ABSTRACT PMID:39556651 | DOI:10.1161/CIRCULATIONAHA.124.069792…
Associations between Leisure and Work Time Activity Behavior and 24 H Ambulatory Blood Pressure among Aging Workers
Med Sci Sports Exerc. 2024 Nov 6. doi: 10.1249/MSS.0000000000003594. Online ahead of print. ABSTRACT Purpose: The associations between work time, leisure-time, and non-workday physical activity (PA) and sedentary behavior (SED) and 24 h ambulatory blood pressure (BP) are not well known. Therefore, the aim of this study was to evaluate…
Sex-specific associations between maternal prenatal inflammation and offspring cortical morphology in youth: A harmonised study across four birth cohorts
Brain Behav Immun. 2024 Nov 4:S0889-1591(24)00692-5. doi: 10.1016/j.bbi.2024.11.010. Online ahead of print. ABSTRACT Maternal immune activation (MIA) during pregnancy is implicated in offspring psychiatric disorders. However, it is unknown to what extent MIA affects neurodevelopment, particularly cerebrocortical anatomy, in the general population, and whether effects differ by sex. The current…
Device-Measured 24-Hour Movement Behaviors and Blood Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium
Circulation. 2024 Nov 6. doi: 10.1161/CIRCULATIONAHA.124.069820. Online ahead of print. ABSTRACT BACKGROUND: Blood pressure (BP)-lowering effects of structured exercise are well-established. Effects of 24-hour movement behaviors captured in free-living settings have received less attention. This cross-sectional study investigated associations between a 24-hour behavior composition comprising 6 parts (sleeping, sedentary behavior,…
