Front Genet. 2023 Nov 2;14:1248701. doi: 10.3389/fgene.2023.1248701. eCollection 2023. ABSTRACT Enteroviral infections have been linked to the development of islet autoimmunity (IA) and type 1 diabetes (T1D), and the coxsackie and adenovirus receptor (CXADR) is one of the ligands used by adenoviruses and enteroviruses for cell internalization. Two CXADR single…
Publications
Publications
Metformin Versus Insulin for Gestational Diabetes: Cognitive and Neuropsychological Profiles of Children Aged 9 years
J Dev Behav Pediatr. 2023 Dec 1;44(9):e642-e650. doi: 10.1097/DBP.0000000000001233. Epub 2023 Nov 28. ABSTRACT OBJECTIVE: We compared cognitive profile and neuropsychological performance in 9-year-old offspring of mothers who were treated with metformin or insulin for gestational diabetes mellitus (GDM). METHODS: A total of 172 children whose mothers were randomly assigned…
Childhood Non-HDL Cholesterol and LDL Cholesterol and Adult Atherosclerotic Cardiovascular Events
Circulation. 2023 Nov 28. doi: 10.1161/CIRCULATIONAHA.123.064296. Online ahead of print. ABSTRACT BACKGROUND: Although low-density lipoprotein cholesterol (LDL-C) remains the primary cholesterol target in clinical practice in children and adults, non-high-density lipoprotein cholesterol (non-HDL-C) has been suggested as a more accurate measure of atherosclerotic cardiovascular disease (ASCVD) risk. We examined the…
Across ages and places: Unpredictability of maternal sensory signals and child internalizing behaviors
J Affect Disord. 2023 Nov 23:S0165-0327(23)01437-4. doi: 10.1016/j.jad.2023.11.068. Online ahead of print. ABSTRACT BACKGROUND: Patterns of sensory inputs early in life play an integral role in shaping the maturation of neural circuits, including those implicated in emotion and cognition. In both experimental animal models and observational human research, unpredictable sensory…
Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection
Nat Commun. 2023 Nov 22;14(1):7630. doi: 10.1038/s41467-023-42763-9. ABSTRACT Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood transcriptome sequencing data to characterize host responses in children…
NMR metabolomic modelling of age and lifespan: a multi-cohort analysis
medRxiv. 2023 Nov 8:2023.11.07.23298200. doi: 10.1101/2023.11.07.23298200. Preprint. ABSTRACT Metabolomic age models have been proposed for the study of biological aging, however they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age models for prediction of chronological…
Lower maternal emotional availability is related to increased attention toward fearful faces during infancy
Infant Behav Dev. 2023 Nov 16;74:101900. doi: 10.1016/j.infbeh.2023.101900. Online ahead of print. ABSTRACT It has been suggested that infants’ age-typical attention biases for faces and facial expressions have an inherent connection with the parent-infant interaction. However, only a few previous studies have addressed this topic. To investigate the association between…
Infant gut microbiota and negative and fear reactivity
Dev Psychopathol. 2023 Nov 17:1-16. doi: 10.1017/S0954579423001396. Online ahead of print. ABSTRACT BACKGROUND: Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine…
Association of work-related psychosocial factors and day-to-day home blood pressure variation: the Finn-Home study
J Hypertens. 2023 Nov 16. doi: 10.1097/HJH.0000000000003619. Online ahead of print. ABSTRACT OBJECTIVES: Stress, and particularly job strain, has been found to associate with ambulatory blood pressure (BP). Moreover, BP is known to vary between days. One potential over-looked factor underlying this day-to-day BP variation could be work-related psychosocial factors.
Maternal depression and anxiety symptoms across pregnancy and the postnatal period: Modest associations between depression symptoms and infant sleep outcomes
Sleep Med. 2023 Oct 12;112:291-300. doi: 10.1016/j.sleep.2023.10.006. Online ahead of print. ABSTRACT Maternal depression and anxiety symptoms are common across the perinatal period and are associated with a raised risk for adverse child outcomes. While substantial evidence exists for child outcomes such as behaviour, language and cognition, infant sleep has…
