Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection

Nat Commun. 2023 Nov 22;14(1):7630. doi: 10.1038/s41467-023-42763-9. ABSTRACT Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood transcriptome sequencing data to characterize host responses in children…

NMR metabolomic modelling of age and lifespan: a multi-cohort analysis

medRxiv. 2023 Nov 8:2023.11.07.23298200. doi: 10.1101/2023.11.07.23298200. Preprint. ABSTRACT Metabolomic age models have been proposed for the study of biological aging, however they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age models for prediction of chronological…

Lower maternal emotional availability is related to increased attention toward fearful faces during infancy

Infant Behav Dev. 2023 Nov 16;74:101900. doi: 10.1016/j.infbeh.2023.101900. Online ahead of print. ABSTRACT It has been suggested that infants’ age-typical attention biases for faces and facial expressions have an inherent connection with the parent-infant interaction. However, only a few previous studies have addressed this topic. To investigate the association between…

Infant gut microbiota and negative and fear reactivity

Dev Psychopathol. 2023 Nov 17:1-16. doi: 10.1017/S0954579423001396. Online ahead of print. ABSTRACT BACKGROUND: Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine…

Association of work-related psychosocial factors and day-to-day home blood pressure variation: the Finn-Home study

J Hypertens. 2023 Nov 16. doi: 10.1097/HJH.0000000000003619. Online ahead of print. ABSTRACT OBJECTIVES: Stress, and particularly job strain, has been found to associate with ambulatory blood pressure (BP). Moreover, BP is known to vary between days. One potential over-looked factor underlying this day-to-day BP variation could be work-related psychosocial factors.

Maternal depression and anxiety symptoms across pregnancy and the postnatal period: Modest associations between depression symptoms and infant sleep outcomes

Sleep Med. 2023 Oct 12;112:291-300. doi: 10.1016/j.sleep.2023.10.006. Online ahead of print. ABSTRACT Maternal depression and anxiety symptoms are common across the perinatal period and are associated with a raised risk for adverse child outcomes. While substantial evidence exists for child outcomes such as behaviour, language and cognition, infant sleep has…

Device-measured physical activity and cardiometabolic health: the Prospective Physical Activity, Sitting, and Sleep (ProPASS) consortium

Eur Heart J. 2023 Nov 10:ehad717. doi: 10.1093/eurheartj/ehad717. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Physical inactivity, sedentary behaviour (SB), and inadequate sleep are key behavioural risk factors of cardiometabolic diseases. Each behaviour is mainly considered in isolation, despite clear behavioural and biological interdependencies. The aim of this study…

Pertrochanteric hip fracture is associated with mobility decline and poorer physical performance 4 to 6 months post-hip fracture

BMC Geriatr. 2023 Nov 8;23(1):722. doi: 10.1186/s12877-023-04415-x. ABSTRACT BACKGROUND: To study the effect of hip fracture type on physical performance, functional ability and change in mobility four to six months after the injury. METHODS: A total of 1331 patients out of consecutive 2052 patients aged ≥ 65 years who underwent…

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