Nat Genet. 2023 Sep 28. doi: 10.1038/s41588-023-01518-4. Online ahead of print. ABSTRACT Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention. Currently, there are only four known risk loci…
Publications
Publications
A proposed pediatric clinical cardiovascular health reference standard
Am J Prev Med. 2023 Sep 24:S0749-3797(23)00382-3. doi: 10.1016/j.amepre.2023.09.019. Online ahead of print. ABSTRACT INTRODUCTION: Clinical cardiovascular health (CVH) is a construct that includes four health factors – systolic and diastolic blood pressure (BP), fasting glucose, total cholesterol, and body mass index [BMI] – which together provide an evidence-based, more…
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Nat Genet. 2023 Sep 25. doi: 10.1038/s41588-023-01531-7. Online ahead of print. NO ABSTRACT PMID:37749248 | DOI:10.1038/s41588-023-01531-7…
Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children
Front Endocrinol (Lausanne). 2023 Sep 6;14:1211015. doi: 10.3389/fendo.2023.1211015. eCollection 2023. ABSTRACT AIMS/HYPOTHESIS: Appearance of multiple islet cell autoantibodies in early life is indicative of future progression to overt type 1 diabetes, however, at varying rates. Here, we aimed to study whether distinct metabolic patterns could be identified in rapid progressors…
Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes
Sci Rep. 2023 Sep 24;13(1):15941. doi: 10.1038/s41598-023-43039-4. ABSTRACT Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging process. To address this concern, we used…
Attention biases for emotional facial expressions during a free viewing task increase between 2.5 and 5 years of age
Dev Psychol. 2023 Sep 21. doi: 10.1037/dev0001598. Online ahead of print. ABSTRACT The normative, developmental changes in affect-biased attention during the preschool years are largely unknown. To investigate the attention bias for emotional versus neutral faces, an eye-tracking measurement and free viewing of paired pictures of facial expressions (i.e., happy,…
DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls
Autoimmunity. 2023 Dec;56(1):2259118. doi: 10.1080/08916934.2023.2259118. Epub 2023 Sep 19. ABSTRACT We elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PTPN22) on CpG site methylation of their proximal promoters in different lymphocyte…
Maternal Perinatal Stress Trajectories and Negative Affect and Amygdala Development in Offspring
Am J Psychiatry. 2023 Sep 6:appiajp21111176. doi: 10.1176/appi.ajp.21111176. Online ahead of print. ABSTRACT OBJECTIVE: Maternal psychological stress during pregnancy is a common risk factor for psychiatric disorders in offspring, but little is known about how heterogeneity of stress trajectories during pregnancy affect brain systems and behavioral phenotypes in infancy. This…
Trajectories of COVID-19 pandemic-related depressive symptoms and potential predictors: the FinnBrain Birth Cohort Study
Soc Psychiatry Psychiatr Epidemiol. 2023 Sep 5. doi: 10.1007/s00127-023-02559-0. Online ahead of print. ABSTRACT PURPOSE: In the context of the COVID-19 pandemic, mental health problems have been reported, and parents of young children may be more vulnerable to psychological distress due to increased caregiving responsibilities. However, research on the heterogeneity…
Association of Tobacco Smoke Exposure with Metabolic Profile from Childhood to Early Adulthood. The Special Turku Coronary Risk Factor Intervention Project (STRIP)
Eur J Prev Cardiol. 2023 Sep 1:zwad285. doi: 10.1093/eurjpc/zwad285. Online ahead of print. ABSTRACT AIMS: To investigate the associations between passive tobacco smoke exposure and daily smoking with a comprehensive metabolic profile, measured repeatedly from childhood to adulthood. METHODS: Study cohort was derived from the Special Turku Coronary Risk Factor…
