Andrology. 2024 Oct 18. doi: 10.1111/andr.13777. Online ahead of print. ABSTRACT BACKGROUND: Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib-treated male patients…
Publications
Publications
Predictors in Youth of Adult Cardiovascular Events
Pediatrics. 2024 Oct 14:e2024066736. doi: 10.1542/peds.2024-066736. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVES: Childhood risk factors are associated with cardiovascular events in adulthood. We compared the utility of a risk model based solely on nonlaboratory risk factors in adolescence versus a model that additionally included lipids to predict cardiovascular…
Changes in food habits during the transition to retirement: the Whitehall II cohort study
J Epidemiol Community Health. 2024 Oct 1:jech-2024-222690. doi: 10.1136/jech-2024-222690. Online ahead of print. ABSTRACT BACKGROUND: The transition to retirement is a significant turning point in life, which may lead to changes in food habits. OBJECTIVE: To examine changes in red meat, fish, vegetables and fruit consumption during the retirement transition…
Neonatal and early infancy antibiotic exposure is associated with childhood atopic dermatitis, wheeze and asthma
Eur J Pediatr. 2024 Sep 28. doi: 10.1007/s00431-024-05775-1. Online ahead of print. ABSTRACT Antibiotics are frequently administered in the neonatal period and early infancy. Little is known about the long-term health consequences of early life antibiotic exposure. The objective is to investigate the association between neonatal and early life (0-6…
Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19
iScience. 2024 Aug 9;27(10):110704. doi: 10.1016/j.isci.2024.110704. eCollection 2024 Oct 18. ABSTRACT We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using…
Predicting early-stage coronary artery disease using machine learning and routine clinical biomarkers improved by augmented virtual data
Eur Heart J Digit Health. 2024 Aug 9;5(5):542-550. doi: 10.1093/ehjdh/ztae049. eCollection 2024 Sep. ABSTRACT AIMS: Coronary artery disease (CAD) is a highly prevalent disease with modifiable risk factors. In patients with suspected obstructive CAD, evaluating the pre-test probability model is crucial for diagnosis, although its accuracy remains controversial. Machine learning…
Food Consumption and Risk of Islet Autoimmunity and Type 1 Diabetes in Children at Increased Genetic Susceptibility for Type 1 Diabetes
J Nutr. 2024 Sep 21:S0022-3166(24)01035-6. doi: 10.1016/j.tjnut.2024.09.018. Online ahead of print. ABSTRACT BACKGROUND: Prospective longitudinal evidence considering the entire childhood food consumption in relation to development of islet autoimmunity (IA or) type 1 diabetes is lacking. OBJECTIVES: We studied the associations of consumption of various foods and their combinations with…
Reciprocal relationships between a child’s engagement with faces and mother-child interaction at 8, 30, and 60 months
Dev Psychol. 2024 Sep 23. doi: 10.1037/dev0001831. Online ahead of print. ABSTRACT Prioritized attention to faces can be viewed as an early-developing marker of social engagement. This behavior is closely linked with early interactions, but there has been little research examining the longitudinal associations between social engagement and parent-child interaction.
Cognitive performance from childhood to old age and intergenerational correlations in the multigenerational Young Finns Study
J Neurol. 2024 Sep 22. doi: 10.1007/s00415-024-12693-7. Online ahead of print. ABSTRACT BACKGROUND: Cognitive performance changes during the lifespan, but the information is gathered from studies on separate age cohorts. Computerized neurocognitive testing enables efficient and similar assessments for all ages. We investigated (i) the effect of age at different…
Sleep duration and sleep loss during pregnancy: a longitudinal FinnBrain birth cohort study
Arch Gynecol Obstet. 2024 Sep 20. doi: 10.1007/s00404-024-07727-4. Online ahead of print. ABSTRACT PURPOSE: To investigate sleep duration and sleep loss during antenatal period and assess associative factors, including maternal characteristic and mood symptoms. METHODS: A cohort of 3038 women was enrolled. Self-reported sleep duration and sleep loss, the latter…
