J Neurol. 2024 Jun 2. doi: 10.1007/s00415-024-12466-2. Online ahead of print. ABSTRACT OBJECTIVE: Sex, age, and education are associated with the level of cognitive performance. We investigated whether these factors modulate the change in cognitive performance in midlife by leveraging the longitudinal data from the Cardiovascular Risk in Young Finns…
Publications
Publications
Caesarean section and risk of type 1 diabetes
Diabetologia. 2024 May 31. doi: 10.1007/s00125-024-06176-7. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: Delivery by Caesarean section continues to rise globally and has been associated with the risk of developing type 1 diabetes and the rate of progression from pre-symptomatic stage 1 or 2 type 1 diabetes to symptomatic stage 3…
Does the effect of adolescent health behaviours on adult cardiometabolic health differ by socioeconomic background? Protocol for a population-based cohort study
BMJ Open. 2024 May 28;14(5):e078428. doi: 10.1136/bmjopen-2023-078428. ABSTRACT INTRODUCTION: Adolescence is a sensitive period for cardiometabolic health. Yet, it remains unknown if adolescent health behaviours, such as alcohol use, smoking, diet and physical activity, have differential effects across socioeconomic strata. Adopting a life-course perspective and a causal inference framework, we…
Determinants of echocardiographic epicardial adipose tissue in a general middle-aged population – The Cardiovascular Risk in Young Finns Study
Sci Rep. 2024 May 25;14(1):11982. doi: 10.1038/s41598-024-61727-7. ABSTRACT Epicardial adipose tissue (EAT) is the cardiac visceral fat depot proposed to play a role in the etiology of various cardiovascular disease outcomes. Little is known about EAT determinants in a general population. We examined cardiometabolic, dietary, lifestyle and socioeconomic determinants of…
Gut inflammation markers, diet, and risk of islet autoimmunity in Finnish children – a nested case-control study
J Nutr. 2024 May 23:S0022-3166(24)00292-X. doi: 10.1016/j.tjnut.2024.05.015. Online ahead of print. ABSTRACT BACKGROUND: Gut dysbiosis and increased intestinal permeability have been reported to precede type 1 diabetes related autoimmunity. Role of gut inflammation in autoimmunity is not understood. OBJECTIVES: To assess whether gut inflammation markers are associated with risk of…
Physical activity and risk of workplace and commuting injuries: a cohort study
Scand J Work Environ Health. 2024 May 23:4163. doi: 10.5271/sjweh.4163. Online ahead of print. ABSTRACT OBJECTIVE: Leisure-time physical activity (PA) has been hypothesized to reduce the likelihood of occupational injuries, but it is unclear whether this association varies between workplace and commuting injuries. The aim of this study was to…
Personalized Intervention Based on Early Detection of Atherosclerosis: JACC State-of-the-Art Review
J Am Coll Cardiol. 2024 May 28;83(21):2112-2127. doi: 10.1016/j.jacc.2024.02.053. ABSTRACT Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide and challenges the capacity of health care systems globally. Atherosclerosis is the underlying pathophysiological entity in two-thirds of patients with CVD. When considering that atherosclerosis develops over decades,…
Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Genome Biol. 2024 May 21;25(1):129. doi: 10.1186/s13059-024-03276-w. NO ABSTRACT PMID:38773652 | DOI:10.1186/s13059-024-03276-w…
Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study
Front Psychiatry. 2024 Apr 25;15:1345159. doi: 10.3389/fpsyt.2024.1345159. eCollection 2024. ABSTRACT BACKGROUND: Studies have shown that cardiovascular health (CVH) is related to depression. We aimed to identify gene networks jointly associated with depressive symptoms and cardiovascular health metrics using the whole blood transcriptome. MATERIALS AND METHODS: We analyzed human blood transcriptomic…
Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies
Nat Commun. 2024 May 7;15(1):3810. doi: 10.1038/s41467-024-47918-w. ABSTRACT Previous studies have revealed heterogeneity in the progression to clinical type 1 diabetes in children who develop islet-specific antibodies either to insulin (IAA) or glutamic acid decarboxylase (GADA) as the first autoantibodies. Here, we test the hypothesis that children who later develop…
