J Nutr. 2024 May 23:S0022-3166(24)00292-X. doi: 10.1016/j.tjnut.2024.05.015. Online ahead of print. ABSTRACT BACKGROUND: Gut dysbiosis and increased intestinal permeability have been reported to precede type 1 diabetes related autoimmunity. Role of gut inflammation in autoimmunity is not understood. OBJECTIVES: To assess whether gut inflammation markers are associated with risk of…
Publications
Publications
Physical activity and risk of workplace and commuting injuries: a cohort study
Scand J Work Environ Health. 2024 May 23:4163. doi: 10.5271/sjweh.4163. Online ahead of print. ABSTRACT OBJECTIVE: Leisure-time physical activity (PA) has been hypothesized to reduce the likelihood of occupational injuries, but it is unclear whether this association varies between workplace and commuting injuries. The aim of this study was to…
Personalized Intervention Based on Early Detection of Atherosclerosis: JACC State-of-the-Art Review
J Am Coll Cardiol. 2024 May 28;83(21):2112-2127. doi: 10.1016/j.jacc.2024.02.053. ABSTRACT Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide and challenges the capacity of health care systems globally. Atherosclerosis is the underlying pathophysiological entity in two-thirds of patients with CVD. When considering that atherosclerosis develops over decades,…
Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Genome Biol. 2024 May 21;25(1):129. doi: 10.1186/s13059-024-03276-w. NO ABSTRACT PMID:38773652 | DOI:10.1186/s13059-024-03276-w…
Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study
Front Psychiatry. 2024 Apr 25;15:1345159. doi: 10.3389/fpsyt.2024.1345159. eCollection 2024. ABSTRACT BACKGROUND: Studies have shown that cardiovascular health (CVH) is related to depression. We aimed to identify gene networks jointly associated with depressive symptoms and cardiovascular health metrics using the whole blood transcriptome. MATERIALS AND METHODS: We analyzed human blood transcriptomic…
Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies
Nat Commun. 2024 May 7;15(1):3810. doi: 10.1038/s41467-024-47918-w. ABSTRACT Previous studies have revealed heterogeneity in the progression to clinical type 1 diabetes in children who develop islet-specific antibodies either to insulin (IAA) or glutamic acid decarboxylase (GADA) as the first autoantibodies. Here, we test the hypothesis that children who later develop…
Changes in Accelerometer-Measured Physical Activity and Sedentary Time Across Retirement Transition as a Predictor of Self-Rated Health
J Phys Act Health. 2024 May 2:1-9. doi: 10.1123/jpah.2023-0558. Online ahead of print. ABSTRACT BACKGROUND: Retirement transition has been shown to associate with changes in physical activity (PA) and self-rated health (SRH), but their interrelationship is less studied. The aim was to investigate changes in accelerometer-measured total PA, moderate to…
sFlt-1 Impairs Neurite Growth and Neuronal Differentiation in SH-SY5Y Cells and Human Neurons
Biosci Rep. 2024 May 3:BSR20240562. doi: 10.1042/BSR20240562. Online ahead of print. ABSTRACT Pre-eclampsia (PE) is a hypertensive disorder of pregnancy which is associated with increased risk of neurodevelopmental disorders in exposed offspring. The pathophysiological mechanisms mediating this relationship are currently unknown, and one potential candidate is the anti-angiogenic factor soluble…
Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data
BMC Med Inform Decis Mak. 2024 May 2;24(1):116. doi: 10.1186/s12911-024-02521-3. ABSTRACT BACKGROUND: Machine learning (ML) classifiers are increasingly used for predicting cardiovascular disease (CVD) and related risk factors using omics data, although these outcomes often exhibit categorical nature and class imbalances. However, little is known about which ML classifier, omics…
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Nat Genet. 2024 Apr 30. doi: 10.1038/s41588-024-01714-w. Online ahead of print. ABSTRACT Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10-8) from the largest single-stage blood pressure (BP) genome-wide association study to…
