Nat Rev Endocrinol. 2024 Nov 4. doi: 10.1038/s41574-024-01045-0. Online ahead of print. ABSTRACT The goal of the TEDDY (The Environmental Determinants of Diabetes in the Young) study is to elucidate factors leading to the initiation of islet autoimmunity (first primary outcome) and those related to progression to type 1 diabetes…
Publications
Publications
Tracking and Transition Probability of Blood Pressure From Childhood to Midadulthood
JAMA Pediatr. 2024 Nov 4. doi: 10.1001/jamapediatrics.2024.4368. Online ahead of print. ABSTRACT IMPORTANCE: Despite its relevance for pediatric blood pressure (BP) screening, the long-term predictive utility and natural progression of pediatric BP classification remain understudied. OBJECTIVE: To evaluate BP tracking from childhood to midadulthood using the American Academy of Pediatrics…
The role of early life factors and green living environment in the development of gut microbiota in infancy: Population-based cohort study
Environ Int. 2024 Oct 22;193:109093. doi: 10.1016/j.envint.2024.109093. Online ahead of print. ABSTRACT OBJECTIVE: Early life microbial exposure influences the composition of gut microbiota. We investigated how early life factors, and the green living environment around infants’ homes, influence the development of gut microbiota during infancy by utilizing data from the…
Higher initial levothyroxine doses and very early treatment start may lead to better cognitive outcomes in children with congenital hypothyroidism
Acta Paediatr. 2024 Nov 1. doi: 10.1111/apa.17479. Online ahead of print. ABSTRACT AIM: This study aimed to assess the cognitive development of individuals with congenital hypothyroidism. METHODS: Using hospital records, we identified 180 patients with congenital hypothyroidism born between 1980 and 2018 in Turku and Kuopio University Hospital catchment areas.
Simulated ischaemia/reperfusion impairs trophoblast function through divergent oxidative stress- and MMP-9-dependent mechanisms
Biosci Rep. 2024 Oct 30:BSR20240763. doi: 10.1042/BSR20240763. Online ahead of print. ABSTRACT Early-onset pre-eclampsia is believed to arise from defective placentation in the 1st trimester, leading to placental ischaemia/reperfusion (I/R) and oxidative stress. However, our current understanding of the effects of I/R and oxidative stress on trophoblast function is ambiguous…
Changes in 24-h Movement Behaviors During Relationship and Parenthood Transitions: A Compositional Data Analysis
Scand J Med Sci Sports. 2024 Nov;34(11):e14751. doi: 10.1111/sms.14751. ABSTRACT There is scarcity of studies using device-based measures to examine how relationship and parenthood transitions modify 24-h movement behaviors. This study examined how the composition of 24-h movement behaviors changes during these life transitions. Young adults (n = 170, mean…
Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures
Sci Rep. 2024 Oct 26;14(1):25463. doi: 10.1038/s41598-024-75496-w. ABSTRACT Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological…
Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31-year follow-up
Aging Cell. 2024 Oct 25:e14394. doi: 10.1111/acel.14394. Online ahead of print. ABSTRACT Evidence is accumulating on the connection of early adversities and harsh family environment with epigenetic ageing. We investigated whether early psychosocial resilience is associated with epigenetic ageing in adulthood. We used the population-based Young Finns data (n =…
Bias in O-Information Estimation
Entropy (Basel). 2024 Sep 30;26(10):837. doi: 10.3390/e26100837. ABSTRACT Higher-order relationships are a central concept in the science of complex systems. A popular method of attempting to estimate the higher-order relationships of synergy and redundancy from data is through the O-information. It is an information-theoretic measure composed of Shannon entropy terms…
Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro
Andrology. 2024 Oct 18. doi: 10.1111/andr.13777. Online ahead of print. ABSTRACT BACKGROUND: Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib-treated male patients…
