Cardiometabolic determinants of aortic and carotid intima-media thickness in adolescence

Atherosclerosis. 2025 May 21;406:120218. doi: 10.1016/j.atherosclerosis.2025.120218. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Comprehensive longitudinal data in healthy populations on cardiometabolic determinants of arterial intima-media thickness (IMT), especially aortic IMT, in adolescence are lacking. We aimed to examine in detail how cardiometabolic risk factors associate with aortic and carotid…

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Polygenic risk for schizophrenia predicting Big Five personality traits in individuals without non-affective psychosis

Schizophr Res. 2025 May 23;281:229-236. doi: 10.1016/j.schres.2025.05.017. Online ahead of print. ABSTRACT BACKGROUND: A high genetic risk for schizophrenia, in complex interplay with environmental factors, has been suggested to explain population-level variation in personality traits among individuals who do not develop schizophrenia-spectrum disorders. We investigated, first, whether polygenic risk for…

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Association of childhood and adult socioeconomic status with adult social connection: a mediation analysis

Am J Epidemiol. 2025 May 14:kwaf106. doi: 10.1093/aje/kwaf106. Online ahead of print. ABSTRACT In this prospective cohort study, we explored associations of childhood socioeconomic status (SES) with social connection in adulthood, and to which extent these associations can be explained by SES in adulthood. We used data from the longitudinal…

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Morbidity-bridging metabolic pathways: linking early cardiovascular disease risk and depression symptoms using a multi-modal approach

Eur Heart J Open. 2025 Apr 16;5(3):oeaf038. doi: 10.1093/ehjopen/oeaf038. eCollection 2025 May. ABSTRACT AIMS: Prevalence of cardiovascular diseases (CVDs) and depression is rising globally. Their co-occurrence associates with poorer outcomes, potentially due to shared metabolic pathways. This study aimed to identify metabolic pathways linking depression symptoms and CVD risk factors.

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Polygenic risk for schizophrenia and subjective well-being in a general population sample

Psychol Med. 2025 May 2;55:e133. doi: 10.1017/S0033291725000911. ABSTRACT BACKGROUND: Previous evidence has reported associations of a polygenic risk score for schizophrenia (PRSSCZ) with negative developmental outcomes, such as psychiatric symptoms, adverse health behaviors, and reduced everyday functioning. We now investigated the relationship of PRSSCZ with subjectively experienced well-being. METHODS: Participants…

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Extremely Early Appearance of Islet Autoantibodies in Genetically Susceptible Children

Pediatr Diabetes. 2023 Dec 11;2023:9973135. doi: 10.1155/2023/9973135. eCollection 2023. ABSTRACT OBJECTIVE: We studied the characteristics of children who developed islet autoantibodies by the age of 0.50 years and hypothesized that the appearance of extremely early islet autoimmunity differs between four birth cohorts within 1994-2019 according to the change in the…

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